Pogba and Sanchez both featured for their national sides, France and Chile respectively, in the international break, with Pogba scoring against Russia.
The pair were both dropped for United's last match against Brighton in the FA Cup Quarter-Final, but have been recalled for the league game at Old Trafford today.
Romelu Lukaku and Jesse Lingard - scorer for England against the Netherlands - round out the attack.
Swansea start with Andre Ayew up front as his brother Jordan serves a suspension.
